ROLE OF SPECIFIC TRANSCRIPTION FACTORS NF-κB AND NRF2 IN MECHANISMS OF DEVELOPMENT OF BRAIN-INJURY INDUCED OXIDATIVE AND NITROSATIVE STRESS

This study is aimed at investigating the effect of specific modulators transcription factors NF-κB and Nrf2 on indicators oxidative-nitrosative stress in periodontal soft tissues early post-traumatic period after experimental model moderate traumatic brain injury (TBI). The experiment was conducted 20 white male Wistar rats weighing 180-220 g, divided into 4 groups: 1st (pseudo-traumatized animals, control 1) exposed to same manipulations (ether anaesthesia, fixation) as series, with exception TBI modelling; 2nd group – modelling (control 2); animals 3rd 4th groups following received intraperitoneal injections for 7 days: inhibitor nuclear translocation ammonium pyrrolidine dithiocarbamate a dose 76 mg/kg inducer factor dimethyl fumarate 15 10 % dimethylsulfoxide solution, respectively. has shown that end (on 7th day), modelled accompanied by development periodontium confirmed an increase production superoxide anion radical all its main sources (microsomes, mitochondria leukocyte NADPH oxidase), elevation NO-synthase activity due inducible isoenzyme whilst under decreased constitutive isoform transition uncoupled state, growth concentration peroxynitrite. introduction (ammonium dimethylfumarate, respectively) significantly reduces signs day): it restricts radical, this enzyme, enhances coupling cNOS, decreases